While on SR388, Samus battles four Omega Metroids shortly before encountering a Queen. These attack by firing energy bursts and by ramming. Samus can defeat the Omega Metroids by firing thirty Missiles to their chest or back.
On the B.S.L Research Station Samus encounters a single Omega Metroid shortly after defeating an SA-X. This one is invulnerable to all of Samus's current weapons. The Omega Metroid takes Samus's energy to a critical level, but it is attacked by an SA-X before it can finish her off. After the SA-X is defeated by the Metroid, Samus absorbs its Core-X, allowing her to regain the Ice Beam and defeat the Metroid.