Metroid Dread, also called Metroid 5, is a 2D Metroid title set to release for the Nintendo Switch on October 8th, 2021. The game is functionally similar to Metroid: Samus Returns, being developed by the same studio, Mercury Steam. Chronologically, the game is set after the events of Metroid Fusion, making Metroid Dread the latest entry in the Metroid timeline.
Metroid Dread retells the story of the 2D Metroid games leading up to it, ending with Metroid Fusion. Now, Samus is dispatched to investigate by a currently unknown party and travels to ZDR. As the only being in the universe with immunity against the X Parasites, Samus seeks to uncover whether they truly still exist. Soon after arriving on ZDR, Samus encounters a hostile, living Chozo (who previously appeared in the Chozo Memories of Metroid: Samus Returns), who attacks her and steals her abilities.  As Samus wakes up and explores the planet in search of a way back to her ship, Samus encounters the E.M.M.I. robots which were built by the Galactic Federation, have gone rogue and now seek to kill her. 
The computerized Adam Malkovich returns in this game as a provider of lore and story-related information. Samus is able to interface with him via Communication Rooms. He will not give Samus orders or objectives like he did in Metroid: Other M and Metroid Fusion. Kraid, who was thought to have been killed after Super Metroid, is also returning.
Dread will conclude the main story arc of the Metroid series that began with the original game, of the connected fates of Samus and the Metroids.
The game plays similarly to Metroid: Samus Returns. Free Aim and Melee Strikes return, as well as a Screw Attack-like move that utilizes the Charge Beam, being able to turn invisible with a Phantom Cloak, and being able to magnetize Samus to certain surfaces and move around on them. The camera can also shift to behind Samus to allow a better look at her environment when using Free Aim.
The E.M.M.I.s are large robots that are alerted by sound. When one is nearby, any sounds Samus makes will alert it, as indicated by a yellow circle that shows around Samus when she moves. If an E.M.M.I. catches sight of Samus, it will charge after her, following her movements. Should Samus be caught, she has a chance to escape by pressing the X Button at the right time, but failure to do so will result in an instant Game Over. E.M.M.I.s cannot enter small spaces that the Morph Ball can get into, and they can be fooled by using the Phantom Cloak.
According to Game Informer, the game has "been in development" since 2005. Only rumors of the game's existence have ever surfaced. In Metroid Prime 3: Corruption, one of Samus's scans hints that "Metroid Project "Dread" is nearing the final stages of completion". Later, Nintendo stated they were not working on any 2D Metroid project for the DS, killing off the rumors.
In an interview about Metroid: Other M, producer Yoshio Sakamoto was asked if this was what became of "Project Dread". Sakamoto announced that the day may come when Dread will hit stores, but it is not the same game as Other M. 
At the 2010 Game Developers Conference, Sakamoto returned to the subject, "not denying" the rumors that Metroid Dread was still in development, but not committing to a release date, saying there's never been an official announcement.
When asked by IGN whether Metroid: Samus Returns, the forthcoming remake of Metroid II: Return of Samus for Nintendo 3DS was linked to Dread, Sakamoto quickly shot down any connection, saying "I think it’s better to say that this is a remake, remastering of Metroid II, a powered-up version of that, and not something to do with the other project." He did, however, indirectly confirm the earlier statement by the anonymous NST developer, about Dread having a dual screen setup with the Map and UI on the bottom screen, and gameplay on the top screen. In a 2018 interview with Hobby Consolas, Sakamoto stated that the DS did not have the technical specifications to make the new Metroid game he had in mind, which he reiterated when Dread was finally announced. He also implied in the same interview that the next game would explain the Chozo Memories ending from Samus Returns.
Much like the case with Metroid 64, any time Dread is mentioned prior to 2021, it seems that replies from game producers and Nintendo seem vague and confusing or blatant denials of the game's existence.
MTV-Retro Studios Interview
Late 2007, MTVNews interviewed a couple of Retro Studios producers on the then-new Metroid Prime 3: Corruption. In part of the interview, MTV had a Q&A session with Mark Pacini (Corruption's game director), Tod Keller (art director), and Bryan Walker (game producer) in which Dread's reference in Corruption was discussed and cast aside as a "fluke".
MTV: What's the story behind the apparent reference in "Metroid Prime 3" to "Metroid Dread," the rumored but never-confirmed 2D game some fans hope is being made at Nintendo?
Pacini: "It's not what you think it means… it was something that was overlooked and wasn't in any way indicating anything about the handheld game. We know no information about the handheld games.
MTV: Are you suggesting that you got in trouble or something?
Pacini: Not at all. We actually had a fictional element of something else in the game that by a large coincidence could be read that we were giving a hint about "Metroid Dread" which was not the case. It's a complete and utter coincidence.
Pacini: That's all I can say on it.
MTV: That only makes me more confused. [laughing] I'll see if I can parse what you just said to me.
Bryan Walker, Producer, Retro Studios: I think the bottom line there was [that there was] no innuendo in the reference that you're mentioning.
MTV: But you guys expected that some people would have a reaction to it. That it would be the stuff of news stories, yes?
Pacini: We didn't think anything of it.
Walker: Purely innocuous, really.
MTV: Really? Honestly?
Walker: We're not that clever. No conspiracy.
MTV: [pause, laughing] You're not pulling my leg here. Definitely innocuous?
- Metroid Dread – Announcement Trailer – Nintendo Switch | E3 2021
- Metroid Dread - Nintendo Treehouse: Live | E3 2021 - Part 1
- "Experiment status report update. Metroid Project "Dread" is nearing the final stages of completion." —Scan of Space Pirate screen (Metroid Prime 3: Corruption)
- Nintendo: New Metroid Is NOT Metroid Dread,
- E3 2009: Metroid: Other M Heavy on Action and Story,
- Yoshio Sakamoto discusses Metroid 64, Metroid Dread and the 3DS,
- Sakamoto: One of the themes we chose to stick with this time [with Metroid: Samus Returns] was utilizing both 3D visuals and a dual screen setup. In fact, I’d been interested in creating a Metroid title that allowed you display the map constantly on a second screen and interact with the elements of the UI by touching them since the time of the original DS.
- MTV's extended interview section with Retro Studios on Corruption