The Sanctuary Entrance is a large room in the Sanctuary Fortress and the resting place of the Keybearer S-Jrs. In the center of the room is a long bridge that spans the gorge separating the two parts of the Sanctuary Entrance. Littering the room are numerous Luminoth Tech Crates, Space Pirate Crates, and containers of Phazon.
During Samus's first visit, a group of Pirate Commandos ambushes her, forcing her to defeat them before she exits. After Samus obtains the Spider Ball, Dark Samus destroys the bridge, forcing Samus to cross using a set of Spider Ball Tracks present in the room. Later, the gap can be crossed by using the Screw Attack.
Once she is in possession of her Power Bombs, Samus can shatter a barrier of Denzium that allows her to reach a "Vigilance" Class Turret. Using this turret, she can destroy several large obstructions, exposing a Power Bomb Expansion, some Luminoth Lore, and the body of S-Jrs.
- "A-Kul tried to send me back to Aether, that I might get reinforcements. Both cadres have been attacked, devastated. The Ing followed me. They came, wearing the skin of beasts. I gave them a good fight, yet, I have failed. May I redeem my honor in the next life. Here, at the fortress entrance, I breathe my last." —S-Jrs's Testament (Metroid Prime 2: Echoes)